Organotypic spinal cord culture using mice
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چکیده
منابع مشابه
Organotypic Spinal Cord Slice Culture to Study Neural Stem/Progenitor Cell Microenvironment in the Injured Spinal Cord
The molecular microenvironment of the injured spinal cord does not support survival and differentiation of either grafted or endogenous NSCs, restricting the effectiveness of the NSC-based cell replacement strategy. Studying the biology of NSCs in in vivo usually requires a considerable amount of time and cost, and the complexity of the in vivo system makes it difficult to identify individual e...
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The objective of this paper is to describe in detail the method of organotypic longitudinal spinal cord slice culture and the scientific basis for its potential utility. The technique is based on the interface method, which was described previously and thereafter was modified in our laboratory. The most important advantage of the presented model is the preservation of the intrinsic spinal cord ...
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Previous studies of the development of primary afferent innervation in the rat spinal cord have primarily focused on the time course of afferent innervation, the onset of reflex activity and the development of transmitter activity. However, the factors that contribute to the development of the dorsoventral termination pattern of morphologically and functionally distinct classes of primary affer...
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Among various strategies employed for spinal cord injury, stem cell therapy is a potential treatment. So far, a variety of stem cells have been evaluated in animal models and humans with spinal cord injury, and epidermal neural crest stem cells represent one of the attractive types in this area. Although these multipotent stem cells have been assessed in several spinal cord injury models by ind...
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2. AIMSOFTHEPROJECT 32 2.1.
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2004
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.124.19